What is the news ? About 2 weeks ago , one of the most popular show of you tube known as INDIA'S GOT  LATENT SHOW has been shut down and the members of these show were taken in the detention of police . Due to their arrest the whole society of bharat has been divided in two parts .

How the controversy started ?  The show which was popularly known as INDIA'S GOT LATENT  was inspired by the international Got Talent franchise and Kill Tony, featured a wide variety of acts, including singing, dancing, magic, comedy and others. This show was hosted by Balraj singh and a famous comedian Samay Raina . In this show many contenders participated and the winner will get prize money on the basis of total number of ticket sold in that show . Everybody was free to speak anything (abusive or non abusive words , vulgar comment on each other and also on parents etc. ) . Many talented persons also participated in this show . But in the 12^th (last episode ) , which was chaired by Samay Raina,  Apoorva Makheeja, Asheesh Chanchlani, Ranveer Allahabadia and Balraj …. Many vulgar comments were passed by Ranveer as well as Apoorva which offended many peoples. They started opposing the vulgarity of this show and many FIRs were filed by many social media influencers. Due to huge pressure by opposition as well as party members, the Phadanvis government issued a notice to all the four judges to come and give clarification about the matter and present their opinions.  Last week Supreme court has also said that the comments passed by these you tubers will badly effect the society . Also the passports of these influencers has been taken by the government .

The division of society on this issue :

Indian society has been divided into two parts. Those who oppose this show say that the influencers are deviating the minds of minors and parents. Their statements can cause a huge decline in the mindset of young people. They are not following any code of conduct. That’s why this show must be suspended.

Another part of society are opposing the government. All the social media influencers including comedians and also of printing media are standing against the suspension of this show. They are saying that why should we take their statements as a serious note. We must see this show as an entertainment show not as a show which inspires anyone. The statements given by them are scripted and they do a lot of work on it , so we must respect their hardworking.

My opinion/Conclusion: Generally,  I don’t like to give opinions on these issues but according to me …. If the government is taking action on their statements I am with them . But a question should be asked to government that everything is in your hand then why should you not stop all these type of show for Indians.  Why are you targeting these influencers only? Why you didn’t ban on the pornographic content ? Why you have not stopped the Orchestra of Bihar which is totally based on vulgarity?

There are many questions to be asked from the peoples who are opposing it that they are very pious is their thoughts? Are they very sensitive so that vulgar comment of social media has badly disrupted their mind ? Does they watch the nudity on social media or not ? I believe that there will be silence in that zone .

And my question to those people also who are supporting the show members . Dear so called mature peoples if you child do such things (said by Ranveer ) will you support him or scold him ? I’d your child will openly abuse anyone or to you did you have courage to bear it? Will you reward him or punish?

Our society is trapped in many pros and cons but firstly we must have remove our impurities of mind then we have a right to comment anyone. We must have open to everyone but not in vulgarity but in sincerity , honesty and truthfulness.  We must have to deny these shows or talks which disturbs our society …….

-Team Yuva Aayeg

Shashwat

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Computational methods such as Quantitative Structure-Activity Relationship (QSAR) and Quantitative Structure-Property Relationship (QSPR) models are used to predict a molecule's physicochemical characteristics or biological activity based on its chemical structure. Toxicology, materials science, pharmaceutical chemistry, and environmental science all make extensive use of these models to speed up the identification and refinement of novel compounds.

100.1) Fundamentals of QSAR/QSPR Models

The structural characteristics of chemical substances and their biological functions, such as toxicity, effectiveness, or receptor binding affinity, are mathematically related in QSAR models. Likewise, QSPR models establish a relationship between molecular structure and physicochemical characteristics such as partition coefficient, boiling point, or solubility. The idea that molecular structure determines molecular behavior is shared by QSAR and QSPR.

100.2) Development

1. Data Collection: From experimental or literary sources, a dataset of chemical structures and the actions or characteristics that go along with them is compiled.

2. Descriptor Calculation: molecule descriptors, which describe attributes including atomic composition, topology, electronic distribution, and molecule form, are numerical values obtained from the chemical structure.

3. Feature Selection: To lower dimensionality and enhance model interpretability, pertinent descriptors are chosen by statistical or machine-learning methods.

4. Model Construction: Regression analysis, neural networks, support vector machines, and other statistical or machine-learning techniques are used to construct mathematical models.

5. Model Validation: Both internal and external validation methods, including cross-validation and test datasets, are used to assess the model's predictive accuracy.

6. Model Application: The model can be used to forecast the characteristics or actions of untested drugs after it has been validated.

100.3) Approaches

1) 2D-QSAR: Makes use of two-dimensional molecular descriptors, including molecular fingerprints and connectivity indices.

2) Three-dimensional structural characteristics, such as molecule conformation and electrostatic potential fields, are incorporated into 3D-QSAR.

3) Machine Learning-Based QSAR/QSPR: To improve prediction accuracy, this approach uses sophisticated algorithms such as random forests, decision trees, and deep learning.

100.4) Applications

1) Drug Discovery: QSAR models aid in the creation of new drug candidates with decreased toxicity and maximized activity.

2) Toxicology: Reduces the need for animal testing by forecasting a chemical's possible toxicity.

3) Environmental Science: Evaluate the impact and fate of chemical contaminants in the environment.

4) Designing novel materials with desired physicochemical properties is made easier by Material Science.

100.5) Challenges

Despite their many benefits, QSAR/QSPR models have drawbacks, including a reliance on high-quality datasets, the potential for overfitting, and difficulties projecting predictions to compounds with different structural makeups. Future developments in big data, artificial intelligence, and molecular simulations will improve QSAR/QSPR models even more, increasing their accuracy and generalizability across a range of scientific fields.

100.6) Conclusion

Introduction:

        In an era where gender equality is gaining momentum across various fields, the Navika Sagar Parikrama 2 initiative stands as a beacon of women's empowerment and resilience. This remarkable expedition involves an all-women crew circumnavigating the globe, showcasing the strength, determination, and capabilities of women in the maritime domain. Building upon the success of the first Navika Sagar Parikrama, this second voyage aims to inspire and empower women worldwide.

Background:

     The Navika Sagar Parikrama initiative was first launched by the Indian Navy to promote maritime consciousness and encourage women to pursue careers in sailing. The inaugural expedition saw a team of six fearless women circumnavigate the globe on the INSV Tarini, covering over 21,600 nautical miles in 254 days. The success of this mission laid the foundation for Navika Sagar Parikrama 2, which aims to continue the legacy of breaking barriers and setting new benchmarks.

The Crew:

The heart and soul of Navika Sagar Parikrama 2 lie in its exceptional crew. Comprising two highly skilled and trained women officers from the Indian Navy, Lt Cdr Roopa A and Lt Cdr Dilna K, this team embodies courage, perseverance, and teamwork. Each member has undergone rigorous training and possesses a deep passion for sailing. Their journey is not just about navigating the seas but also about navigating through stereotypes and societal expectations.

The Journey:

   Navika Sagar Parikrama 2 involves a meticulously planned route that takes the crew across some of the most challenging waters on the planet. Starting from the Naval Ocean Sailing Node, INS Mandovi near Panaji, Goa, the voyage was flagged off on October 2, 2024. The journey covers the Atlantic, Pacific, and Indian Oceans, passing through the Cape of Good Hope and Cape Horn. The crew also achieved a significant milestone by crossing Point Nemo, the Oceanic Pole of Inaccessibility, on January 30, 2025.

Point Nemo, named after Jules Verne's fictional character Captain Nemo, is the farthest point from any landmass on Earth. Located in the South Pacific Ocean, it lies approximately 2,688 kilometers from the nearest landmasses: Ducie Island, Motu Nui (Easter Island), and Maher Island off the coast of Antarctica. This remote location is so isolated that the closest human presence is often aboard the International Space Station orbiting above. The waters around Point Nemo are known for their extreme remoteness and minimal marine life, making it a unique and challenging point to navigate. The journey is not without its challenges, including extreme weather conditions, navigation hurdles, and long stretches of solitude. However, each challenge presents an opportunity for the crew to demonstrate their resilience and skill.

Empowerment and Inspiration:

   One of the core objectives of Navika Sagar Parikrama 2 is to empower women and inspire future generations. By successfully completing this voyage, the crew sends a powerful message that women can achieve anything they set their minds to. Their journey serves as a source of inspiration for young girls and women, encouraging them to pursue their dreams, no matter how unconventional they may be.

Technological and Environmental Aspects:

   Navika Sagar Parikrama 2 is not just about human endurance; it also highlights the importance of technological advancements and environmental consciousness. The sailboat, INSV Tarini, is equipped with state-of-the-art navigation and communication systems, ensuring the safety and efficiency of the voyage. Additionally, the crew is committed to promoting sustainable practices, including minimizing plastic usage and studying marine ecosystems along their route.

Impact and Legacy:

    The impact of Navika Sagar Parikrama 2 extends far beyond the duration of the voyage. It challenges traditional gender roles and redefines what women can achieve in the maritime industry. The initiative's success will pave the way for more women to take up sailing and other unconventional careers, ultimately contributing to a more inclusive and diverse workforce.

Conclusion:

   "Sailing into History: The Remarkable Navika Sagar Parikrama 2" encapsulates a journey of courage, resilience, and empowerment. As the crew navigates through treacherous waters and defies societal norms, they leave an indelible mark on maritime history. This expedition is a testament to the boundless potential of women and a beacon of inspiration for future generations. The world watches in awe as these remarkable women sail into history.

-Team Yuva Aayeg

Praveen Kumar Maurya

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What is the news?   Recently, pune, a metropolitan city of Maharashtra,  saw a huge number of cases of GBS Syndrome.

Let’s know about this Syndrome in detail …

About the Syndrome: The GBS Syndrome stands for – Guillian Barre's Syndrome. The origin of this Syndrome is not clear. It is a rare neurological disorder. In this Syndrome , person's immune system attacks on their peripheral nerves which leads in weakening of muscles and in severe cases it may be the cause of paralysis.

In autoimmune condition , the body’s immune system attacks on its own cells . In the case of GBS , immune system destroys myelin sheath which is a fatty layer .

It generally occurs after viral infection or bacterial infection.  According to the world health organisation , infection with bacteria called CAMPYLOBACTER JEJUNI( causing a disease ….. gastroenteritis) is a major risk factor or the people having flu , viral infection from cytomegalovirus , epstein-barr virus and also the zika virus are also the major risk factors for GBS Syndrome.

The bacteria is generally found in contaminated food and also in the water.

This disease or Syndrome is more common in adults and males  . Generally the cases are 1 or 2 in 10000 peoples .

GBS may be life threatening when it affects the autonomic nervous system which controls the blood pressure and also the heart beat.

How is it treated? The most concerning part comes here when we know that that there is no any particular method by which this Syndrome can be cured.

But many people has been recovered after suffering via this syndrome treatment primarily include plasma exchange and intravenous immunoglobulin therapy.  In plasma exchange or plasmapheresis the plasma is ejected out , treated and then again it is injected in the body. This removes the antibodies from the plasma that are Atta king the nerves. Intravenous immunoglobulin therapy involves injecting the immunoglobulin , which are the proteins that body makes to identify the pathogens. This help decreases the immune system’s attack on nerves. Supportive treatment is also given and rehab including physical and occupational therapy may be required. But the recovery may take a long time.

Way forward: Since , the reason for this Syndrome is contaminated food and water , so we must have to keep these things away from our house. WHO has also said that GBS is life threatening.  People suffering from this disease may be monitored and cured as early as possible. If you experience sudden muscle that gets worsen in few days , contact immediately to doctor.

Team Yuva Aaveg-

Shashwat Tripathi

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